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🔬 Science & Medicine

KAT6A (MOZ) — Histone Acetyltransferase and Developmental Regulator

KAT6A (lysine acetyltransferase 6A), also known as MOZ (monocytic leukemia zinc finger protein), is a MYST-family histone acetyltransferase essential for hematopoietic stem cell self-renewal, craniofacial development, and neurogenesis. Mutations in KAT6A cause a syndromic intellectual disability, and chromosomal translocations involving KAT6A are recurrent drivers of acute myeloid leukemia.

8 min read