Results for "DNA damage"
2 articles found
KAT5 (Tip60) — Histone Acetyltransferase and DNA Damage Control
KAT5 (lysine acetyltransferase 5), also known as Tip60 (Tat-interactive protein 60 kDa), is a MYST-family histone acetyltransferase that acetylates histone H4 and H2A, playing central roles in DNA double-strand break repair, apoptosis, transcriptional regulation, and stem cell maintenance. KAT5 is the catalytic subunit of the NuA4/TIP60 chromatin remodeling complex and functions as a tumor suppressor frequently inactivated in human cancers.
KAT8 (MOF or MYST1) — H4K16 Acetyltransferase, Dosage Compensation and Genome Stability
KAT8 (lysine acetyltransferase 8), also known as MOF (males absent on the first) or MYST1, is a MYST-family histone acetyltransferase and the principal enzyme responsible for histone H4 lysine 16 acetylation (H4K16ac) in mammals. Operating in the MSL and NSL complexes, KAT8 regulates dosage compensation, transcription, DNA repair, and stem cell maintenance, and mutations in its complex subunits cause human neurodevelopmental syndromes.