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KAT7 (lysine acetyltransferase 7), also known as HBO1 (histone acetyltransferase binding to ORC1) or MYST2, is a MYST-family enzyme and the principal acetyltransferase for histone H3 lysine 14 (H3K14ac) in mammals. Operating within BRPF- or JADE-containing complexes, KAT7 is required for DNA replication licensing, hematopoietic stem cell self-renewal, and embryonic development.