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KAT5 (lysine acetyltransferase 5), also known as Tip60 (Tat-interactive protein 60 kDa), is a MYST-family histone acetyltransferase that acetylates histone H4 and H2A, playing central roles in DNA double-strand break repair, apoptosis, transcriptional regulation, and stem cell maintenance. KAT5 is the catalytic subunit of the NuA4/TIP60 chromatin remodeling complex and functions as a tumor suppressor frequently inactivated in human cancers.