Results for "MOF"

KAT8 (MOF or MYST1) — H4K16 Acetyltransferase, Dosage Compensation and Genome Stability

KAT8 (lysine acetyltransferase 8), also known as MOF (males absent on the first) or MYST1, is a MYST-family histone acetyltransferase and the principal enzyme responsible for histone H4 lysine 16 acetylation (H4K16ac) in mammals. Operating in the MSL and NSL complexes, KAT8 regulates dosage compensation, transcription, DNA repair, and stem cell maintenance, and mutations in its complex subunits cause human neurodevelopmental syndromes.