Results for "MYST"
5 articles found
KAT5 (Tip60) — Histone Acetyltransferase and DNA Damage Control
KAT5 (lysine acetyltransferase 5), also known as Tip60 (Tat-interactive protein 60 kDa), is a MYST-family histone acetyltransferase that acetylates histone H4 and H2A, playing central roles in DNA double-strand break repair, apoptosis, transcriptional regulation, and stem cell maintenance. KAT5 is the catalytic subunit of the NuA4/TIP60 chromatin remodeling complex and functions as a tumor suppressor frequently inactivated in human cancers.
KAT6B (MORF or MYST4) — Histone Acetyltransferase and Epigenetic Regulator
KAT6B (lysine acetyltransferase 6B), also known as MORF or MYST4, is a MYST-family histone acetyltransferase paralogous to KAT6A that acetylates histone H3K23. Heterozygous loss-of-function mutations cause two clinically distinct human syndromes — Say-Barber-Biesecker-Young-Simpson (SBBYSS) syndrome and genitopatellar syndrome — both characterized by severe intellectual disability and skeletal abnormalities.
KAT8 (MOF or MYST1) — H4K16 Acetyltransferase, Dosage Compensation and Genome Stability
KAT8 (lysine acetyltransferase 8), also known as MOF (males absent on the first) or MYST1, is a MYST-family histone acetyltransferase and the principal enzyme responsible for histone H4 lysine 16 acetylation (H4K16ac) in mammals. Operating in the MSL and NSL complexes, KAT8 regulates dosage compensation, transcription, DNA repair, and stem cell maintenance, and mutations in its complex subunits cause human neurodevelopmental syndromes.
KAT7 (HBO1 or MYST2) — a major histone H3K14 Acetyltransferase
KAT7 (lysine acetyltransferase 7), also known as HBO1 (histone acetyltransferase binding to ORC1) or MYST2, is a MYST-family enzyme and the principal acetyltransferase for histone H3 lysine 14 (H3K14ac) in mammals. Operating within BRPF- or JADE-containing complexes, KAT7 is required for DNA replication licensing, hematopoietic stem cell self-renewal, and embryonic development.
KAT6A (MOZ or MYST3) — Histone Acetyltransferase and Epigenetic Regulator
KAT6A (lysine acetyltransferase 6A), also known as MOZ (monocytic leukemia zinc finger protein), is a MYST-family histone acetyltransferase essential for hematopoietic stem cell self-renewal, craniofacial development, and neurogenesis. Mutations in KAT6A cause a syndromic intellectual disability, and chromosomal translocations involving KAT6A are recurrent drivers of acute myeloid leukemia.