Results for "hematopoiesis"
2 articles found
KAT7 (HBO1 or MYST2) — a major histone H3K14 Acetyltransferase
KAT7 (lysine acetyltransferase 7), also known as HBO1 (histone acetyltransferase binding to ORC1) or MYST2, is a MYST-family enzyme and the principal acetyltransferase for histone H3 lysine 14 (H3K14ac) in mammals. Operating within BRPF- or JADE-containing complexes, KAT7 is required for DNA replication licensing, hematopoietic stem cell self-renewal, and embryonic development.
KAT6A (MOZ or MYST3) — Histone Acetyltransferase and Epigenetic Regulator
KAT6A (lysine acetyltransferase 6A), also known as MOZ (monocytic leukemia zinc finger protein), is a MYST-family histone acetyltransferase essential for hematopoietic stem cell self-renewal, craniofacial development, and neurogenesis. Mutations in KAT6A cause a syndromic intellectual disability, and chromosomal translocations involving KAT6A are recurrent drivers of acute myeloid leukemia.